Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation-Reference-Cited by-同舟云学术

Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation

Published:2019-03 Issue:3 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zeng Sheng¹,Soetaert Karine²,Ravon Faustine¹,Vandeput Marie³,Bald Dirk⁴,Kauffmann Jean-Michel³,Mathys Vanessa²,Wattiez Ruddy⁵,Fontaine Véronique¹^ORCID

Affiliation:

1. Microbiology, Bioorganic and Macromolecular Chemistry Research Unit, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium

2. Sciensano, Tuberculosis and Mycobacteria Unit, Brussels, Belgium

3. Pharmacognosy, Bioanalysis and Drug Discovery Research Unit, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium

4. Department of Molecular Cell Biology, Amsterdam Institute for Molecules, Medicines and Systems, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

5. Department of Proteomics and Microbiology, University of Mons, Mons, Belgium

Abstract

Accumulating evidence suggests that the bactericidal activity of some antibiotics may not be directly initiated by target inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as hypoxia and starvation.

Funder

Les Amis des Instituts Pasteur à Bruxelles

China Scholarship Council

Fonds De La Recherche Scientifique - FNRS

EC | European Regional Development Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01841-18

Reference63 articles.