High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children-Reference-Cited by-同舟云学术

High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ursing Johan¹²³^ORCID,Rombo Lars⁴⁵,Eksborg Staffan⁶,Larson Lena¹,Bruvoll Anita¹,Tarning Joel⁷⁸^ORCID,Rodrigues Amabelia¹,Kofoed Poul-Erik¹⁹

Affiliation:

1. Projecto de Saúde de Bandim, Indepth Network, Bissau, Guinea-Bissau

2. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

3. Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden

4. Centre for Clinical Research, Sörmland County Council, Eskilstuna, Sweden

5. Uppsala University, Uppsala, Sweden

6. Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Karolinska Institutet, Stockholm, Sweden

7. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

8. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

9. Department of Paediatrics, Kolding Hospital, Frederiksberg, Denmark

Abstract

Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter ( pfcrt ) 76T allele. The tolerability of 50 (double the standard dose) and 70 mg/kg total chloroquine doses were assessed in this study. Fifteen 4- to 8-year-old children with uncomplicated malaria were given 10 mg/kg of chloroquine twice daily for 2 days and 5 mg/kg twice daily on the third day.

Funder

Anthony and Ann Dunne Foundation for World Health

Bill and Melinda Gates Foundation

Stockholms Läns Landsting

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01846-19

Reference31 articles.

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