Heterologous Production and Functional Characterization of Ageritin, a Novel Type of Ribotoxin Highly Expressed during Fruiting of the Edible Mushroom Agrocybe aegerita-Reference-Cited by-同舟云学术

Heterologous Production and Functional Characterization of Ageritin, a Novel Type of Ribotoxin Highly Expressed during Fruiting of the Edible Mushroom Agrocybe aegerita

Published:2019-11 Issue:21 Volume:85 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Tayyrov Annageldi¹,Azevedo Sophie¹,Herzog Robert²³,Vogt Eva¹,Arzt Simon⁴,Lüthy Peter¹,Müller Pie⁵⁶,Rühl Martin⁴,Hennicke Florian²⁷,Künzler Markus¹^ORCID

Affiliation:

1. Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland

2. Junior Research Group Genetics and Genomics of Fungi, Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Frankfurt am Main, Germany

3. Department of Environmental Biotechnology, TU Dresden, Zittau, Germany

4. Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Gießen, Gießen, Germany

5. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland

6. University of Basel, Basel, Switzerland

7. Institute of Ecology, Evolution and Diversity, Goethe University, Frankfurt am Main, Germany

Abstract

Our results suggest a pronounced organismal specificity of a protein toxin with a very conserved intracellular molecular target. The molecular details of the toxin-target interaction will provide important insight into the mechanism of action of protein toxins and the ribosome. This insight might be exploited to develop novel bioinsecticides.

Funder

Swiss National Science Foundation

Senckenberg Gesellschaft für Naturforschung

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01549-19

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