Molecular Mechanism of Chloramphenicol and Thiamphenicol Resistance Mediated by a Novel Oxidase, CmO, in Sphingomonadaceae

Author:

Ma Xiaodan12,Zhang Liying12,Ren Yijun12,Yun Hui3,Cui Hanlin4,Li Qian12,Guo Yuanqiang56,Gao Shuhong12,Zhang Fengliang12,Wang Aijie124,Liang Bin12ORCID

Affiliation:

1. State Key Laboratory of Urban Water Resource and Environment, School of Civil and Environmental Engineering, Harbin Institute of Technology Shenzhen, Shenzhen, China

2. Shenzhen Key Laboratory of Organic Pollution Prevention and Control, School of Civil and Environmental Engineering, Harbin Institute of Technology Shenzhen, Shenzhen, China

3. Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China

4. State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, China

5. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China

6. Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China

Abstract

Rising levels of antibiotic resistance are undermining ecological and human health as a result of the indiscriminate usage of antibiotics. Various resistance mechanisms have been characterized—for example, genes encoding proteins that degrade antibiotics—and yet, this requires further exploration.

Funder

National Natural Science Foundation of China

Shenzhen Municipal Science and Technology Innovation Council | Shenzhen Science and Technology Innovation Program

Shenzhen Overseas High-level Talents Research Startup Program

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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