Schlafen 11 Restricts Flavivirus Replication-Reference-Cited by-同舟云学术

Schlafen 11 Restricts Flavivirus Replication

Published:2019-08 Issue:15 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Valdez Federico¹,Salvador Julienne¹,Palermo Pedro M.¹,Mohl Jonathon E.²,Hanley Kathryn A.³,Watts Douglas¹,Llano Manuel¹

Affiliation:

1. Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA

2. Department of Bioinformatics, The University of Texas at El Paso, El Paso, Texas, USA

3. Department of Biology, New Mexico State University, Las Cruces, New Mexico, USA

Abstract

We provide evidence that the cellular protein Schlafen 11 (Slfn11) impairs replication of flaviviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV). However, replication of single-stranded negative RNA viruses was not affected. Specifically, Slfn11 decreases the infectivity of WNV potentially by preventing virus-induced modifications of the host tRNA repertoire that could lead to enhanced viral protein folding. Furthermore, we demonstrate that Slfn11 is not the limiting factor of this novel broad antiviral pathway.

Funder

Keelung Hong Fellowship

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00104-19

Reference51 articles.

1. The Schlafen Family of Proteins and Their Regulation by Interferons

2. Schlafen, a New Family of Growth Regulatory Genes that Affect Thymocyte Development