Affiliation:
1. Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
The stability to β-lactamase hydrolysis of HR 756, a new cephalosporin antibiotic, was compared to the β-lactamase stability of cefoxitin and cefuroxime. HR 756, cefoxitin, and cefuroxime were not hydrolyzed by Richmond type I, III, IV, and V β-lactamases. Antibacterial activity of HR 756 correlated well with resistance to β-lactamase hydrolysis except against
Pseudomonas aeruginosa
. HR 756, cefoxitin, and cefuroxime inhibited type I β-lactamases, but not type III, IV, or V enzymes. HR 756 was the most active inhibitor.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
142 articles.
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