Affiliation:
1. Department of Physiological Chemistry, University of Wisconsin, Madison, Wisconsin 53706
Abstract
Approximately 15 to 20 different species of small (4 to 7
S
) RNAs have been purified by two-dimensional polyacrylamide gel electrophoresis of RNA isolated from virions of Schmidt-Ruppin D strain of Rous sarcoma virus. Each species of small RNA has been isolated free of 70
S
RNA; nine of them, including 5
S
and 7
S
RNAs, were also found associated with the 70
S
genomic RNA. Most of the 4
S
RNAs are present at an average of less than one copy per virion. The 4
S
RNAs have T1 RNase (EC 2.7.7.26) fingerprints, which are very similar to those of tRNAs. One of the smallest 4
S
RNAs, which can act as a primer for initiation of RNA-directed DNA synthesis, is associated with the 70
S
RNA in 1 to 2 copies per complex, whereas an additional 6 to 8 copies of this molecule are free.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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