Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants-Reference-Cited by-同舟云学术

Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants

Published:2018-09 Issue:9 Volume:56 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Fabre Adrien¹²,Oleastro Monica³^ORCID,Nunes Alexandra⁴,Santos Andrea³,Sifré Elodie¹²,Ducournau Astrid¹²,Bénéjat Lucie¹²,Buissonnière Alice¹²,Floch Pauline¹²,Mégraud Francis¹²,Dubois Véronique⁵,Lehours Philippe¹²

Affiliation:

1. CHU de Bordeaux, National Reference Center for Campylobacter and Helicobacter, Bordeaux, France

2. INSERM, University of Bordeaux, UMR1053 Bordeaux Research in Translational Oncology, BaRITOn, Bordeaux, France

3. National Reference Laboratory of Gastrointestinal Infections, Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal

4. Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal

5. CNRS UMR5234, University of Bordeaux, Bordeaux, France

Abstract

A whole-genome sequencing (WGS) approach was conducted in order to identify the molecular determinants associated with antimicrobial resistance in 12 multidrug-resistant Campylobacter jejuni and Campylobacter coli isolates, with a focus on aminoglycoside resistance determinants. Two variants of a new aminoglycoside phosphotransferase gene [ aph ( 2 ″)- Ii 1 and aph ( 2 ″)- Ii 2 ] putatively associated with gentamicin resistance were found.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00390-18

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