The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria-Reference-Cited by-同舟云学术

The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Fay Allison¹,Philip John²,Saha Priya³,Hendrickson Ronald C.²,Glickman Michael S.¹^ORCID,Burns-Huang Kristin³^ORCID

Affiliation:

1. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA

2. Microchemistry and Proteomics Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA

3. Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA

Abstract

AMR is a global problem, especially for TB. Here, we show that mycobacterial chaperones support AMR in M. smegmatis , a nonpathogenic model of M. tuberculosis , the causative agent of TB.

Funder

HHS | National Institutes of Health

MSKCC Cancer Center Support Grant

Abby and Howard P. Milstein Program in Chemical Biology and Translational Medicine

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00123-21

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