Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis

Author:

Chakraborty Arijit12ORCID,Kabashi Asel1,Wilk Samuel1,Rahme Laurence G.123ORCID

Affiliation:

1. Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

2. Shriners Hospitals for Children Boston, Boston, Massachusetts, USA

3. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

This work sheds new light on how P. aeruginosa limits bacterial clearance in macrophages through 2-aminoacetophenone (2-AA), a secreted signaling molecule by this pathogen that is regulated by the quorum-sensing transcription factor MvfR. The action of 2-AA on the lipid biosynthesis gene Scd1 and the autophagic genes ULK1 and Beclin1 appears to secure the reduced intracellular clearance of P. aeruginosa by macrophages.

Funder

NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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