Y-Box Binding Protein 1 Interacts with Dengue Virus Nucleocapsid and Mediates Viral Assembly

Author:

Diosa-Toro Mayra1ORCID,Kennedy Debbie R.2,Chuo Vanessa1,Popov Vsevolod L.3,Pompon Julien4ORCID,Garcia-Blanco Mariano A.1256ORCID

Affiliation:

1. Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore

2. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

3. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

4. MIVEGEC, Univ. Montpellier, IRD, CNRS, Montpellier, France

5. Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA

6. Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

The global incidence of dengue virus (DENV) infections has steadily increased over the past decades representing an enormous challenge for public health. During infection, DENV viral RNA interacts with numerous host RNA binding proteins (RBPs) that aid viral replication and thus constitute potential molecular targets to curb infection.

Funder

NMRC Singapore

The Dutch Research Council

NIH/NIAID

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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