Polymicrobial Aggregates in Human Saliva Build the Oral Biofilm

Author:

Simon-Soro Aurea12,Ren Zhi1,Krom Bastiaan P.3,Hoogenkamp Michel A.3,Cabello-Yeves Pedro J.2,Daniel Scott G.4,Bittinger Kyle4,Tomas Inmaculada5,Koo Hyun16,Mira Alex27

Affiliation:

1. Biofilm Research Laboratories, Department of Orthodontics, Divisions of Community Oral Health & Pediatric Dentistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Center for Advanced Research in Public Health, FISABIO Foundation, Valencia, Spain

3. Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

4. Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

5. Oral Sciences Research Group, Special Needs Unit, Department of Surgery and Medical-Surgical Specialties, School of Medicine and Dentistry, Universidade de Santiago de Compostela, Health Research Institute Foundation of Santiago (FIDIS), Santiago de Compostela, Spain

6. Center for Innovation & Precision Dentistry, School of Dental Medicine and School of Engineering & Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

7. CIBER Center for Epidemiology and Public Health, Madrid, Spain

Abstract

Microbes in biological fluids can be found as aggregates. How these multicellular structures bind to surfaces and initiate the biofilm life cycle remains understudied.

Funder

Spanish Ministry of Economy and Competitiveness

HHS | NIH | National Institute of Dental and Craniofacial Research

NWO Earth and Life Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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