Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status-Reference-Cited by-同舟云学术

Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Regan Jessica¹,DeJarnette Christian²,Luna-Tapia Arturo³,Parker Josie E.⁴,Reitler Parker²,Barnett Stacey⁵,Tucker Katie M.³,Kelly Steven L.⁴,Palmer Glen E.³^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA

2. Department of Molecular Immunology and Biochemistry, College of Graduate Health Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA

3. Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA

4. Institute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom

5. Laboratory Animal Care Unit, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA

Abstract

Mutations that completely inactivate Erg3p enable the prevalent human pathogen C. albicans to endure the azole antifungals in vitro . However, such null mutants are less frequently identified in azole-resistant clinical isolates than other resistance mechanisms, and previous studies have reported conflicting outcomes regarding antifungal resistance of these mutants in animal models of infection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00115-22

Reference39 articles.

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4. Y132H substitution inCandida albicanssterol 14Î±-demethylase confers fluconazole resistance by preventing binding to haem

5. The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity

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