Adaptation of Nontypeable <i>Haemophilus influenzae</i> in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2-Reference-Cited by-同舟云学术

Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Murphy Timothy F.¹^ORCID,Kirkham Charmaine¹,D’Mello Adonis²^ORCID,Sethi Sanjay³⁴,Pettigrew Melinda M.⁵^ORCID,Tettelin Hervé²

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University at Buffalo, The State University of New York, Buffalo, New York, USA

2. Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

3. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University at Buffalo, The State University of New York, Buffalo, New York, USA

4. Department of Medicine, Veterans Affairs Western New York Healthcare System, Buffalo, New York, USA

5. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA

Abstract

Nontypeable Haemophilus influenzae (NTHi) persists in the lower airways of adults with chronic obstructive pulmonary disease (COPD) for months to years, increasing airway inflammation that accelerates the progressive loss of lung function. Understanding the mechanisms of persistence in human airways by NTHi is critical in developing novel interventions.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00140-23

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