Enterovirus 2A pro Cleavage of the YTHDF m 6 A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling-Reference-Cited by-同舟云学术

Enterovirus 2A pro Cleavage of the YTHDF m 6 A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kastan Jonathan P.¹²^ORCID,Tremblay Martine W.²,Brown Michael C.¹,Trimarco Joseph D.³,Dobrikova Elena Y.¹,Dobrikov Mikhail I.¹,Gromeier Matthias¹^ORCID

Affiliation:

1. Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA

2. University Program in Genetics and Genomics, Duke University Medical Center, Durham, North Carolina, USA

3. Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

Abstract

It is believed that ∼7,000 messenger RNAs (mRNAs) are subject to N 6 -methyladenosine modification. The biological significance of this remains mysterious.

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00116-21

Reference42 articles.

1. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

2. Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses