Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects

Author:

Liu Ruikang1,Americo Jeffrey L.1,Earl Patricia L.1,Villani Jack1,Cotter Catherine A.1,Moss Bernard1ORCID

Affiliation:

1. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Attenuated live viruses make effective vaccines, although concerns exist due to infrequent complications, particularly in individuals with immunological defects. Such complications occurred with smallpox vaccines, which were shown to be comprised of populations of variants.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference30 articles.

1. Jenner E. 1798. An inquiry into the causes and effects of the variolae vaccinae, a disease discovered in some of the western countries of England, particularly near Gloucestershire, and known by the name of the cow pox, London, p 213–240. In Camac CNB (ed), Classics of medicine and surgery, 1959. Dover, New York, NY.

2. The Origins of Vaccinia Virus

3. Evolution of and Evolutionary Relationships between Extant Vaccinia Virus Strains

4. Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines

5. Complications of Smallpox Vaccination, 1968

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