Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

Author:

Rochman Nash D.1ORCID,Faure Guilhem2ORCID,Wolf Yuri I.1ORCID,Freddolino Peter L.34ORCID,Zhang Feng25678ORCID,Koonin Eugene V.1ORCID

Affiliation:

1. National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, USA

2. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

3. Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA

4. Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA

5. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

6. McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

7. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

8. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

Abstract

Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide. We employed a computational approach to assess the risk of antibody escape resulting from mutations in the receptor-binding domain of the spike protein of the wild-type SARS-CoV-2 virus as well as the Delta, Gamma, and Omicron variants.

Funder

National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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