Origin and Dissemination of Chloroquine-Resistant Plasmodium falciparum with Mutant pfcrt Alleles in the Philippines-Reference-Cited by-同舟云学术

Origin and Dissemination of Chloroquine-Resistant Plasmodium falciparum with Mutant pfcrt Alleles in the Philippines

Published:2005-05 Issue:5 Volume:49 Page:2102-2105
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chen Nanhua¹,Wilson Danny W.²,Pasay Cielo³,Bell David²,Martin Laura B.²,Kyle Dennis¹⁴,Cheng Qin¹

Affiliation:

1. Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Enoggera

2. Malaria and Scabies Group, Infectious Diseases Unit, Queensland Institute of Medical Research, Herston, Queensland, Australia

3. Department of Parasitology, The Research Institute for Tropical Medicine, Manila, Philippines

4. Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland

Abstract

ABSTRACT The pfcrt allelic type and adjacent microsatellite marker type were determined for 82 Plasmodium falciparum isolates from the Philippines. Mutant pfcrt allelic types P1a and P2a/P2b were dominant in different locations. Microsatellite analysis revealed that P2a/P2b evolved independently in the Philippines, while P1a shared common ancestry with Papua New Guinea chloroquine-resistant parasites.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.5.2102-2105.2005

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