Context-Dependent Action of Scc4 Reinforces Control of the Type III Secretion System-Reference-Cited by-同舟云学术

Context-Dependent Action of Scc4 Reinforces Control of the Type III Secretion System

Published:2020-07-09 Issue:15 Volume:202 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Gao Leiqiong¹,Cong Yanguang¹²,Plano Gregory V.³,Rao Xiancai¹⁴,Gisclair Lyndsey N.¹,Schesser Bartra Sara³,Macnaughtan Megan A.⁵,Shen Li¹

Affiliation:

1. Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

2. Precision Medicine Center, Traditional Chinese Medicine Hospital affiliated with Southwest Medical University, Luzhou, China

3. Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida, USA

4. Department of Microbiology, Army Medical University, Chongqing, China

5. Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, USA

Abstract

The T3SS is a key virulence factor required for C. trachomatis infection. The control of the T3SS has not been well studied in this obligate intracellular pathogen. Here, we show that Scc4 plays a major role for precise control of the pathogenic T3SS at the levels of gene expression and effector secretion through genetically separable protein networks, allowing a fast adaptive mode of C. trachomatis development during infection in human epithelial cells.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00132-20

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