Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for Treatment of Uncomplicated Plasmodium falciparum Malaria in Eastern Cambodia-Reference-Cited by-同舟云学术

Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for Treatment of Uncomplicated Plasmodium falciparum Malaria in Eastern Cambodia

Published:2019-03 Issue:3 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Leang Rithea¹,Mairet-Khedim Melissa²,Chea Huch¹,Huy Rekol¹,Khim Nimol²,Mey Bouth Denis³,Dorina Bustos Maria⁴,Ringwald Pascal⁵,Witkowski Benoit²

Affiliation:

1. National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia

2. Institut Pasteur in Cambodia, Phnom Penh, Cambodia

3. World Health Organization, Phnom Penh, Cambodia

4. World Health Organization, Bangkok, Thailand

5. World Health Organization, Geneva, Switzerland

Abstract

In Cambodia, multidrug-resistant Plasmodium falciparum undermines the treatment of uncomplicated malaria, and new therapeutic options are needed. Pyronaridine-artesunate has not previously been evaluated in eastern Cambodia.

Funder

World Health Organization

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02242-18

Reference33 articles.

1. Kingdom of Cambodia Ministry of Health. 2016. Cambodia malaria elimination action framework 2016–2020. Kingdom of Cambodia Ministry of Health, Phnom Penh, Cambodia. http://www.malariaeradication.org/knowledge-hub/cambodia-malaria-elimination-action-framework-2016-2020.

2. World Health Organization. 2015. Strategy for malaria elimination in the Greater Mekong Subregion (2015–2030). World Health Organization, Geneva, Switzerland. http://iris.wpro.who.int/bitstream/handle/10665.1/10945/9789290617181_eng.pdf;jsessionid=3204C3285C2E6290730A3453BFFD279D?sequence=1.

3. Evidence of Artemisinin-Resistant Malaria in Western Cambodia

4. A Major Genome Region Underlying Artemisinin Resistance in Malaria

5. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

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