Emergence of Macrolide-Resistant Streptococcus pyogenes Strains in French Children

Author:

Bingen Edouard1,Bidet Philippe1,Mihaila-Amrouche Liliana2,Doit Catherine1,Forcet Samuel1,Brahimi Naïma1,Bouvet Anne2,Cohen Robert3

Affiliation:

1. Laboratoire d'Etudes de Génétique Bactérienne dans les infections de l'enfant (EA3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré

2. Centre National de Référence des Streptocoques, Université Paris 5, Service de Microbiologie, Hôtel-Dieu, Paris

3. Service de Microbiologie, Centre Hospitalier de Créteil, Créteil, France

Abstract

ABSTRACT We studied the antimicrobial susceptibility of 322 Streptococcus pyogenes throat isolates from French children and their serotype and genomic diversity. A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB , ermA , and mefA , respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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