CD4 + T Cells and the Proinflammatory Cytokines Gamma Interferon and Interleukin-6 Contribute to Alveolar Bone Loss in Mice

Author:

Baker Pamela J.1,Dixon Mark1,Evans R. Todd2,Dufour Lisa3,Johnson Ellis14,Roopenian Derry C.4

Affiliation:

1. Biology Department, Bates College, Lewiston, Maine 042401;

2. Department of Oral Biology, State University of New York, Buffalo, New York 142142;

3. School of Dental Hygiene, University of New England, Portland, Maine 040923; and

4. The Jackson Laboratory, Bar Harbor, Maine 046094

Abstract

ABSTRACT In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis . Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss than did immunocompetent mice after oral infection, suggesting that lymphocytes contribute to this process. Bone loss after oral infection was decreased in mice deficient in major histocompatibility complex (MHC) class II-responsive CD4 + T cells, but no change in bone loss was observed in mice deficient in MHC class I-responsive CD8 + T cells or NK1 + T cells. Mice lacking the cytokine gamma interferon or interleukin-6 also demonstrated decreased bone loss. These results suggest that the adaptive immune response, and in particular CD4 + T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection. The studies also reinforce the utility of the mouse oral infection model in dissecting the pathobiology of periodontal disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference46 articles.

1. Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice;Baker P. J.;Arch. Oral Biol.,1994

2. Baker P. J. S. Carter M. Dixon R. T. Evans and D. C. Roopenian. Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis -induced alveolar bone loss in mice. Oral Microbiol. Immunol. in press.

3. Baker P. J. M. Dixon and D. C. Roopenian. Genetic control of susceptibility to alveolar bone loss in mice. Submitted for publication.

4. Baron R. Vignery A. Horowitz M. Lymphocytes macrophages and the regulation of bone remodeling Bone and mineral research annual 2: a yearly survey of developments in the field of bone and mineral metabolism. Peck W. A. 1983 175 243 Elsevier Science Publishers New York N.Y

5. The effects of immunosuppressive drugs on periodontal inflammation in human renal allograft patients;Been V.;J. Periodontol.,1982

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