The gut microbiota contributes to the infection of bovine viral diarrhea virus in mice

Author:

Zhang Zecai1234ORCID,Huang Jiang156,Li Chuang12,Zhao Zhicheng12,Cui Yueqi12,Yuan Xueying12,Wang Xue12,Liu Yu1234,Zhou Yulong1234,Zhu Zhanbo1234ORCID

Affiliation:

1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China

2. Key Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural affairs, Daqing, China

3. Engineering Research Center for Prevention and Control of Cattle Diseases, Heilongjiang Province, Daqing, China

4. Heilongjiang Province Cultivating Collaborative Innovation Center for The Beidahuang Modern Agricultural Industry Technology, Daqing, China

5. Agriculture and Rural Bureau of Sinan County, Sinan County, Guizhou, China

6. Animal Health Supervision Institute of Sinan County, Sinan County, Guizhou, China

Abstract

Whether the high infection rate of BVDV is related to gut microbiota has not been reported. In addition, most studies on BVDV focus on in vitro experiments, which limits the study of its prevention and control strategy and its pathogenic mechanism. In this study, we successfully confirmed the causal relationship between gut microbiota and BVDV infection as well as the potential molecular mechanism based on a mouse model of BVDV infection and a mouse model of gut microbiota dysbiosis. Meanwhile, a mouse model which is more susceptible to BVDV provided in this study lays an important foundation for further research on prevention and control strategy of BVDV and its pathogenesis. In addition, the antiviral effect of butyrate, the metabolites of butyrate-producing bacteria, has been further revealed. Overall, our findings provide a promising prevention and control strategy to treat this infectious disease which is distributed worldwide.

Funder

Natural Science Foundation of the Heilongjiang Province of China

Heilongjiang Bayi Agricultural University Talent Research Start-up Fund

MOST | National Natural Science Foundation of China

Heilongjiang Province's "Jie Bang Gua Shuai" Science and Technology Research Project

Publisher

American Society for Microbiology

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