BRD4S Interacts with Viral E2 Protein To Limit Human Papillomavirus Late Transcription

Abstract

Human papillomaviruses (HPV) have coevolved with their host by using cellular factors like bromodomain-containing protein 4 (BRD4) to control viral processes, such as genome maintenance, gene expression, and replication. Here, we show that, in addition to the C-terminal motif in BRD4, the phospho-dependent interaction domain in BRD4 interacts with E2 proteins, which enable the recruitment of BRD4S, the short isoform of BRD4, to E2.