ISOLATION OF ENTEROVIRUSES FROM THE “NORMAL” BABOON ( PAPIO DOGUERA )

Abstract

Fuentes-Marins , R. (Southwest Foundation for Research and Education, San Antonio, Texas), A. R. Rodriguez, S. S. Kalter, A. Hellman, and R. A. Crandell . Isolation of enteroviruses from the “normal” baboon ( Papio doguera ). J. Bacteriol. 85: 1045–1050. 1963.—In a study designed to determine whether the baboon ( Papio doguera ) would be suitable for use as a model of human virus infections, the normal enterovirus flora was determined. Five agents were isolated from 101 stool samples: four from the African group and one from the African-African group. None of the stool samples from the Domestic group of animals was found to contain any agents. On the basis of their biological characterizations (animal source, cytopathic effect, plaque formation, and antigenic relationships), the isolates were separated into two groups. Accordingly, prototype strains AA153 and A13 were designated for the African-African and African groups, respectively. These viruses have not been found to be related to any known human viruses. Their relationship to organisms isolated from other animals, especially primates, awaits study. The failure to detect latent viruses in preparations of baboon kidney cell cultures suggests a relatively “clean” animal which may be used with safety in preparation of vaccine for human administration.