Affiliation:
1. U .S. Public Health Service, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana
Abstract
Anacker
, R. L. (Rocky Mountain Laboratory, Hamilton, Mont.), W. T.
Haskins, D. B. Lackman, E. Ribi, and E. G. Pickens
. Conversion of the phase I antigen of
Coxiella burnetii
to hapten by phenol treatment. J. Bacteriol.
85:
1165–1170. 1963.—Trichloroacetic acid extracts of
Coxiella burnetii
are converted to hapten by treatment with phenol. Such extracts react, like the original trichloroacetic acid extract, at high dilution in the complement-fixation test and produce zones of precipitate with specific antibody in gel diffusion tests; but, unlike the parent extract, injection of the phenol-treated extract neither induces resistance to challenge in guinea pigs nor antibody formation in guinea pigs, rabbits, or mice. This loss of antigenicity is correlated with removal of protein from the original product.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference16 articles.
1. Antigenic and skin-reactive properties of fractions of Coxiella burnettii;ANACKER R. L.;J. Immunol.,1962
2. BENENSON A. S. 1959. Q fever vaccine: efficacy and present status p. 47-60. In J. E. Smadel [ed.] Medical Science Publication No. 6 Symposium on Q Fever. U.S. Government Printing Office Washington D.C.
3. Study on the antigenic structure of Coxiella burnetii. II. Purification of phase I antigenic component obtained by means of trichloroacetic acid;BREZINA R., S.;Acta Virol.,1962
4. Identification of Rickettsia rickettsii in the wood tick, Dermacentor andersoni, by means of fluorescent antibody;BURGDORFER W.;J. Infect. Diseases,1960
5. DISCHE Z. 1955. New color reactions for determinations of sugars in polysaccharides p. 313-358. In D. Glick [ed.] Methods of biochemical analysis vol. 2. Interscience Publishers Inc. New York.
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