Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance-Reference-Cited by-同舟云学术

Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance

Published:2016-04 Issue:4 Volume:60 Page:2524-2527
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bottery Michael J.¹,Wood A. Jamie¹²,Brockhurst Michael A.¹

Affiliation:

1. Department of Biology, University of York, York, United Kingdom

2. Department of Mathematics, University of York, York, United Kingdom

Abstract

ABSTRACT Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

Funder

Wellcome Trust

European Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02441-15

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