The Rok Protein of Bacillus subtilis Represses Genes for Cell Surface and Extracellular Functions-Reference-Cited by-同舟云学术

The Rok Protein of Bacillus subtilis Represses Genes for Cell Surface and Extracellular Functions

Published:2005-03-15 Issue:6 Volume:187 Page:2010-2019
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Albano Mark¹,Smits Wiep Klaas²,Ho Linh T. Y.¹,Kraigher Barbara³,Mandic-Mulec Ines³,Kuipers Oscar P.²,Dubnau David¹

Affiliation:

1. The Public Health Research Institute, Newark, New Jersey

2. Groningen Biomolecular Sciences and Biotechnology Institute, Department of Genetics, University of Groningen, Haren, The Netherlands

3. Department of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia

Abstract

ABSTRACT Rok is a repressor of the transcriptional activator ComK and is therefore an important regulator of competence in Bacillus subtilis (T. T. Hoa, P. Tortosa, M. Albano, and D. Dubnau, Mol. Microbiol. 43:15-26, 2002). To address the wider role of Rok in the physiology of B. subtilis , we have used a combination of transcriptional profiling, gel shift experiments, and the analysis of lacZ fusions. We demonstrate that Rok is a repressor of a family of genes that specify membrane-localized and secreted proteins, including a number of genes that encode products with antibiotic activity. We present evidence for the recent introduction of rok into the B. subtilis-Bacillus licheniformis-Bacilllus amyloliquefaciens group by horizontal transmission.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.187.6.2010-2019.2005

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