The Concentration of Apolipoprotein A-I Decreases during Experimentally Induced Acute-Phase Processes in Pigs

Author:

Carpintero R.1,Piñeiro M.1,Andrés M.1,Iturralde M.1,Alava M. A.1,Heegaard P. M. H.2,Jobert J. L.3,Madec F.3,Lampreave F.1

Affiliation:

1. Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain

2. Danish Institute for Food and Veterinary Research, Copenhagen V, Denmark

3. French Agency for Food Safety, BP 53, Zoôpoles les Croix, 22440 Ploufragan, France

Abstract

ABSTRACT In this work, apolipoprotein A-I (ApoA-I) was purified from pig sera. The responses of this protein after sterile inflammation and in animals infected with Actinobacillus pleuropneumoniae or Streptococcus suis were investigated. Decreases in the concentrations of ApoA-I, two to five times lower than the initial values, were observed at 2 to 4 days. It is concluded that ApoA-I is a negative acute-phase protein in pigs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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