Activation of NFAT-Dependent Gene Expression by Nef: Conservation among Divergent Nef Alleles, Dependence on SH3 Binding and Membrane Association, and Cooperation with Protein Kinase C-θ-Reference-Cited by-同舟云学术

Activation of NFAT-Dependent Gene Expression by Nef: Conservation among Divergent Nef Alleles, Dependence on SH3 Binding and Membrane Association, and Cooperation with Protein Kinase C-θ

Published:2001-03-15 Issue:6 Volume:75 Page:3034-3037
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Manninen Aki¹,Huotari Päivi¹,Hiipakka Marita¹,Renkema G. Herma¹,Saksela Kalle¹²

Affiliation:

1. Institute of Medical Technology, University of Tampere, FIN-33014 Tampere,1 and

2. Department of Clinical Chemistry, Tampere University Hospital, FIN-33521 Tampere,2 Finland

Abstract

ABSTRACT Here we show that the potential to regulate NFAT is a conserved property of different Nef alleles and that Nef residues involved in membrane targeting and SH3 binding are critical for this function. Cotransfection of an activated protein kinase C-θ (PKC-θ) with Nef implicated PKC-θ as a possible physiological cofactor of Nef in promoting NFAT-dependent gene expression and T-cell activation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.6.3034-3037.2001

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