Impact of Clarithromycin Resistance on Eradication of Helicobacter pylori in Infected Adults-Reference-Cited by-同舟云学术

Impact of Clarithromycin Resistance on Eradication of Helicobacter pylori in Infected Adults

Published:2005-04 Issue:4 Volume:49 Page:1600-1603
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lee Jong Hwa¹²,Shin Ji-Hyun¹,Roe Im Hwan³,Sohn Seung Ghyu²,Lee Jung Hun²,Kang Geun Ho²,Lee Han-Ki²,Jeong Byeong Chul²,Lee Sang Hee²

Affiliation:

1. Research Center of Gastroenterology

2. Department of Biological Sciences, Myongji University, Yongin, Kyunggido, Republic of Korea

3. Department of Gastroenterology, Dankook University College of Medicine, Cheonan, Choongnamdo

Abstract

ABSTRACT The outcome of Helicobacter pylori infection was analyzed in 114 dyspeptic patients treated with triple-drug therapy including clarithromycin. Clarithromycin resistance (in 20.2% of our isolates) was mainly caused by an A2142G mutation in the 23S rRNA gene of H . pylori . H . pylori eradication was obtained in all patients with clarithromycin-susceptible isolates but not in any patients with clarithromycin-resistant isolates ( P = 0.0001). Therefore, it would be useful to conduct H . pylori antimicrobial susceptibility testing of the first gastric biopsy culture before choosing the first three drugs for therapy of infected patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.4.1600-1603.2005

Reference23 articles.

1. Debets-Ossenknopp, Y. J., A. J. Herscheid, R. G. Pot, E. J. Kuipers, J. G. Kusters, and C. M. Vandenbroucke-Grauls. 1999. Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxicillin, tetracycline, and trovafloxacin in The Netherlands. J. Antimicrob. Chemother.43:511-515.

2. Dore, M. P., G. Leandro, G. Realdi, A. R. Sepulveda, and D. Y. Graham. 2000. Effect of pretreatment antibiotic resistance to metronidazole and clarithromycin on outcome of Helicobacter pylori therapy. Dig. Dis. Sci.45:68-76.

3. Drumm, B. S., S. Koletzko, and G. Oderda, on behalf of the European Pediatric Task Force on Helicobacter pylori. 2001. Helicobacter pylori infection in children: a consensus statement. J. Pediatr. Gastroenterol. Nutr.30:207-213.

4. New Site of Modification of 23S rRNA Associated with Clarithromycin Resistance of Helicobacter pylori Clinical Isolates

5. Graham, D. Y., and W. A. Qureshi. 2000. Antibiotic-resistant H. pylori infection and its treatment. Curr. Pharm. Des.15:1537-1544.

Cited by 56 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Detection of Clarithromycin Resistance in <i>Helicobacter pylori</i> Using MmaxSure™ <i>H. pylori</i> & ClaR Assay;Digestive Diseases;2024

2. Does Types of 23S-Ribosomal RNA Point Mutations Affect Helicobacter pylori Eradication Rate in Clarithromycin-Based Triple Therapy?;The Korean Journal of Helicobacter and Upper Gastrointestinal Research;2023-12-10

3. Quantitative multiplex real-time polymerase chain reaction assay for the detection of Helicobacter pylori and clarithromycin resistance;BMC Microbiology;2023-05-27

4. Novel Mutations Conferring Amoxicillin Resistance in Helicobacter pylori in South Korea;Antibiotics;2023-04-13

5. Effects of prior antibiotic use on clarithromycin resistance in Helicobacter pylori;Helicobacter;2023-03-28