Double Copies of bla KPC-3 ::Tn 4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy-Reference-Cited by-同舟云学术

Double Copies of bla KPC-3 ::Tn 4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy

Published:2016-01 Issue:1 Volume:60 Page:646-649
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fortini Daniela¹,Villa Laura¹,Feudi Claudia¹,Pires João²³,Bonura Celestino⁴,Mammina Caterina⁴,Endimiani Andrea²^ORCID,Carattoli Alessandra¹²

Affiliation:

1. Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy

2. Institute for Infectious Diseases, University of Bern, Bern, Switzerland

3. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

4. Department of Sciences for Health Promotion and Mother-Child Care G. D'Alessandro, University of Palermo, Palermo, Italy

Abstract

ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.

Funder

Swiss National Science Foundation

Ministero della Salute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01886-15

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