Plasmid-mediated high-level resistance to erythromycin in Escherichia coli

Author:

Andremont A,Gerbaud G,Courvalin P

Abstract

Escherichia coli BM2195 was found to be resistant to high levels of erythromycin. This new resistance phenotype was due to the constitutive synthesis of an erythromycin esterase which inactivates the antibiotic. The gene conferring resistance to erythromycin in this strain is carried on a 61-kilobase self-transferable plasmid, pIP1100, belonging to incompatibility group X.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference10 articles.

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4. Enzymatic hydrolysis of erythromycin by a strain of Escherichia coli: a new mechanism of resistance;Barthdlemy P.;J. Antibiot.,1984

5. Elimination of ethidium bromide of antibiotic resistance in enterobacteria and staphylococci;Bouanchaud D. H.;J. Gen. Microbiol.,1969

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