Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA-Reference-Cited by-同舟云学术

Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tang Liudi¹²,An Ping³,Zhao Qiong¹,Winkler Cheryl A.³,Chang Jinhong¹,Guo Ju-Tao¹^ORCID

Affiliation:

1. Department of Experimental Therapeutics, Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA

2. Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

3. Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

Abstract

Elimination or functional inactivation of cccDNA minichromosomes in HBV-infected hepatocytes is essential for the cure of chronic hepatitis B virus (HBV) infection. However, lack of knowledge of the molecular mechanisms of cccDNA metabolism and regulation hampers the development of antiviral drugs to achieve this therapeutic goal.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01261-22

Reference69 articles.

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