Implementation of SARS-CoV2 Screening in K–12 Schools Using In-School Pooled Molecular Testing and Deconvolution by Rapid Antigen Test

Author:

Pollock Nira R.1ORCID,Berlin David2,Smole Sandra C.3,Madoff Lawrence C.3,Brown Catherine3,Henderson Kelsey2,Larsen Elizabeth4,Hay Jeremiah4,Gabriel Stacey5,Gawande Atul A.26,Lennon Niall J.5ORCID

Affiliation:

1. Department of Laboratory Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

2. CIC Health, Cambridge, Massachusetts, USA

3. Massachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA

4. Executive Office of Health and Human Services, Massachusetts Department of Health and Human Services, Boston, Massachusetts, USA

5. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

6. Ariadne Labs, Brigham and Women’s Hospital and Harvard TH Chan School of Public Health, Boston, Massachusetts, USA

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) testing is one component of a multilayered mitigation strategy to enable safe in-person school attendance for the K–12 school population. However, costs, logistics, and uncertainty about effectiveness are potential barriers to implementation.

Funder

Commonwealth of Massachusetts

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

U.S. Department of Health and Human Services

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference12 articles.

1. US Department of Health and Human Services. 2021. Biden administration to invest more than $12 billion to expand COVID-19 testing. https://www.hhs.gov/about/news/2021/03/17/biden-administration-invest-more-than-12-billion-expand-covid-19-testing.html. Accessed 13 April 2021.

2. Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2

3. A pooled testing strategy for identifying SARS-CoV-2 at low prevalence

4. Sinnott-Armstrong N Klein DL Hickey B. 2020. Evaluation of group testing for SARS-CoV-2 RNA. bioRxiv doi:10.1101/2020.03.27.20043968.

5. Considerations for Group Testing: A Practical Approach for the Clinical Laboratory

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