A Case of Epstein-Barr Virus (EBV)-Associated Thymic Carcinoid and Investigation of Existence of EBV-Infected Cells in Thymus and Thymic Tumors-Reference-Cited by-同舟云学术

A Case of Epstein-Barr Virus (EBV)-Associated Thymic Carcinoid and Investigation of Existence of EBV-Infected Cells in Thymus and Thymic Tumors

Published:2004-06 Issue:6 Volume:42 Page:2850-2854
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Takeuchi Hiroaki¹,Fujita Hiroshi²,Iwasaki Fumio³,Takeuchi Takako⁴,Imadome Ken-Ichi⁵,Okumiya Toshika⁶,Matsui Tomohiro⁷,Takahashi Mutsuo⁷

Affiliation:

1. Department of Clinical Laboratory Medicine, Faculty of Medicine, Kochi University School of Medicine, Nankoku, Kochi

2. Departments of Internal Medicine

3. Pathology, Shimonoseki-saiseikai Hospital, Shimonoseki

4. Department of Pathology, Shimonosekishi-ishikai Hospital, Shimonoseki

5. Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo

6. Department of Laboratory Sciences, Kumamoto University School of Health Sciences, Kumamoto

7. Department of Laboratory Sciences, Faculty of Health Sciences, Yamaguchi University School of Medicine, Yamaguchi, Japan

Abstract

ABSTRACT We describe the first case of Epstein-Barr virus (EBV)-associated thymic carcinoid tumor found by in situ hybridization (ISH) on paraffin-embedded sections. ISH revealed that both tumor cells and infiltrated lymphocytes were EBV positive, while a few EBV-infected lymphocytes were detected in 2 of 11 thymuses and 1 of 11 thymomas.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.42.6.2850-2854.2004

Reference28 articles.

1. Ban, S., Y. Goto, K. Kamada, M. Takahama, H. Watanabe, T. Iwahori, and H. Takeuchi. 1999. Systemic granulomatous arteritis associated with Epstein-Barr virus infection. Virchows Arch.434:249-254.

2. Borisch, B., T. Kirchner, A. Marx, and H. K. Muller-Hermelink. 1990. Absence of the Epstein-Barr virus genome in the normal thymus, thymic epithelial tumors, thymic lymphoid hyperplasia in a European population. Virchows Arch. B Cell. Pathol. Incl. Mol. Pathol.59:359-365.

3. Borza, C. M., and L. M. Hutt-Fletcher. 2002. Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nature Med.8:594-599.

4. Chan, A. O., S. G. Kim, A. Bedeir, J. P. Issa, S. R. Hamilton, and A. Rashid. 2003. CpG island methylation in carcinoid and pancreatic endocrine tumors. Oncogene22:924-934.

5. Chen, P. C., C. C. Pan, A. H. Yang, L. S. Wang, and H. Chiang. 2002. Detection of Epstein-Barr virus genome within thymic epithelial tumours in Taiwanese patients by nested PCR, PCR in situ hybridization, and RNA in situ hybridization. J. Pathol.197:684-688.

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