Corrected and Republished from: “A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal <i>Streptococcus pneumoniae</i> Challenge”-Reference-Cited by-同舟云学术

Corrected and Republished from: “A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge”

Published:2022-01-25 Issue:1 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chan Win-Yan¹,Entwisle Claire²,Ercoli Giuseppe¹,Ramos-Sevillano Elise¹,McIlgorm Ann²,Cecchini Paola²,Bailey Christopher²,Lam Oliver³,Whiting Gail³,Green Nicola⁴,Goldblatt David⁴,Wheeler Jun X.³,Brown Jeremy S.¹

Affiliation:

1. Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School Rayne Institute, London, United Kingdom

2. ImmunoBiology Ltd., Babraham, Cambridge, United Kingdom

3. National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, United Kingdom

4. UCL Great Ormond Street Institute of Child Health, London, United Kingdom

Abstract

Current vaccination against Streptococcus pneumoniae uses vaccines based on capsular polysaccharides from selected serotypes and has led to nonvaccine serotype replacement disease. We have investigated an alternative serotype-independent approach, using multiple-antigen vaccines (MAV) prepared from S. pneumoniae TIGR4 lysates enriched for surface proteins by a chromatography step after culture under conditions that induce expression of heat shock proteins (Hsp; thought to be immune adjuvants).

Funder

RCUK | Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00846-18a

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