Genetic Basis of Antibiotic Resistance in Streptococcus agalactiae Strains Isolated in a French Hospital

Author:

Poyart Claire123,Jardy Laurence2,Quesne Gilles2,Berche Patrick23,Trieu-Cuot Patrick13

Affiliation:

1. Laboratoire Mixte Pasteur-Necker de Recherche sur les Streptocoques et Streptococcies, Faculté de Médecine Necker-Enfants Malades, 75730 Paris Cedex 15

2. Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades

3. INSERM U570, Faculté de Médecine, Necker-Enfants Malades, 75015 Paris, France

Abstract

ABSTRACT The genetic basis of antibiotic resistance in 113 unrelated group B streptococci was studied by PCR. Ninety-four strains were resistant to tetracycline-minocycline, and tet (M) was detected in 85% of these isolates. Seventeen erythromycin-resistant strains contained the erm (B), erm (TR), or mef (A) gene. Eleven strains exhibited high-level resistance to kanamycin due to the presence of the aphA3 gene; eight of these strains were also highly resistant to streptomycin; aad - 6- related sequences were detected in seven strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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