Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8 + T-Cell Epitopes-Reference-Cited by-同舟云学术

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8 + T-Cell Epitopes

Published:2007-04 Issue:7 Volume:81 Page:3667-3672
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Honeyborne Isobella¹,Prendergast Andrew¹,Pereyra Florencia²,Leslie Alasdair¹,Crawford Hayley¹,Payne Rebecca¹,Reddy Shabashini³,Bishop Karen³,Moodley Eshia³,Nair Kriebashnie³,van der Stok Mary³,McCarthy Noel⁴,Rousseau Christine M.⁵,Addo Marylyn²,Mullins James I.⁵,Brander Christian²,Kiepiela Photini³,Walker Bruce D.²,Goulder Philip J. R.¹²³

Affiliation:

1. Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom

2. Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129

3. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban 4013, South Africa

4. Department of Zoology, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom

5. Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070

Abstract

ABSTRACT To better understand relationships between CD8 + T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8 + response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02689-06

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