Contribution of RNA-RNA Interactions Mediated by the Genome Packaging Signals for the Selective Genome Packaging of Influenza A Virus

Author:

Miyamoto Sho12ORCID,Muramoto Yukiko134,Shindo Keiko1,Fujita-Fujiharu Yoko134,Morikawa Takeshi1,Tamura Ryoma13,Gilmore Jamie L.1,Nakano Masahiro134,Noda Takeshi134ORCID

Affiliation:

1. Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

2. Department of Molecular Virology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

3. Laboratory of Ultrastructural Virology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

4. CREST, Japan Science and Technology Agency, Kawaguchi, Japan

Abstract

While numerous viral genomes comprise a single genome segment, the influenza A virus possesses eight segmented genomes. Influenza A virus can benefit from having a segmented genome because the segments can reassort with other strains of the influenza virus to create new genetically distinct strains.

Funder

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

MEXT | Japan Science and Technology Agency

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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