Latent Tuberculosis Infection and Associated Factors in Patients with Systemic Lupus Erythematosus: a Multicenter, Cross-Sectional Study

Author:

Zhang Lifan123,Ma Yanan1,Jiang Nan14,Zou Xiaoqing15,Zhang Yueqiu1,Zhang Fengchun6,Zeng Xiaofeng6,Zhao Yan6,Liu Shengyun7,Zuo Xiaoxia8,Wu Huaxiang9,Wu Lijun10,Li Hongbin11,Zhang Zhiyi12,Chen Sheng13,Zhu Ping14,Zhang Miaojia15,Qi Wencheng16,Liu Yi17,Liu Huaxiang18,Shi Xiaochun12ORCID,Liu Xiaoqing123

Affiliation:

1. Division of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

2. Centre for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

3. Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China

4. 4+4 Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

5. School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

6. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, People’s Republic of China

7. Department of Rheumatology and Immunology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China

8. Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China

9. Department of Rheumatology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of China

10. Department of Rheumatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, People’s Republic of China

11. Department of Rheumatology and Immunology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, People’s Republic of China

12. Department of Rheumatology and Immunology, First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China

13. Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

14. Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China

15. Department of Rheumatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China

16. Department of Rheumatology, Tianjin First Central Hospital, Tianjin, People’s Republic of China

17. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

18. Department of Rheumatology, Qilu Hospital of Shandong University, Ji’nan, People’s Republic of China

Abstract

The burden of tuberculosis and systemic lupus erythematosus in China ranks among the top three in the world. Therefore, active screening for LTBI and preventive intervention in SLE patients are of great significance in China.

Funder

National High Level Hospital Clinical Research Funding

National Science and Technology Major Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference32 articles.

1. Global tuberculosis report. 2021. Geneva: World Health Organization; 2021. Licence: CC BY-NC-SA 3.0 IGO. https://www.who.int/publications/i/item/9789240037021.

2. Global epidemiology of systemic lupus erythematosus

3. Expert consensus on the estimation of the national burden on latent tuberculosis infection;Chinese Center for Disease Control and Prevention;Zhongguo Fang Lao Za Zhi,2022

4. The risk of infections in adult patients with systemic lupus erythematosus: systematic review and meta-analysis

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