A Markerless CRISPR-Mediated System for Genome Editing in Candida auris Reveals a Conserved Role for Cas5 in the Caspofungin Response-Reference-Cited by-同舟云学术

A Markerless CRISPR-Mediated System for Genome Editing in Candida auris Reveals a Conserved Role for Cas5 in the Caspofungin Response

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ennis Craig L.¹²³,Hernday Aaron D.¹³,Nobile Clarissa J.¹³^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA

2. Quantitative and Systems Biology Graduate Program, University of California, Merced, California, USA

3. Health Sciences Research Institute, University of California, Merced, California, USA

Abstract

Candida auris is a recently emerged multidrug-resistant fungal pathogen capable of causing life-threatening systemic infections in humans. Few tools are available for genome editing in C. auris .

Funder

HHS | NIH | National Institute of General Medical Sciences

Kamangar Family

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01820-21

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2. Candida auris: Epidemiology, biology, antifungal resistance, and virulence

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4. Simultaneous Emergence of Multidrug-ResistantCandida aurison 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses

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