<i>Plasmodium</i> Parasite Malate-Quinone Oxidoreductase Functionally Complements a Yeast Deletion Mutant of Mitochondrial Malate Dehydrogenase-Reference-Cited by-同舟云学术

Plasmodium Parasite Malate-Quinone Oxidoreductase Functionally Complements a Yeast Deletion Mutant of Mitochondrial Malate Dehydrogenase

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ito Takeshi¹²^ORCID,Kajita Sayaka¹³,Fujii Minori¹³,Shinohara Yasuo¹²

Affiliation:

1. Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

2. Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, Japan

3. Faculty of Pharmaceutical Sciences, Tokushima University, Tokushima, Japan

Abstract

We constructed a model organism to study the physiological role and function of P. falciparum malate-quinone oxidoreductase (PfMQO) in a yeast expression system. PfMQO is actively expressed in yeast mitochondria and functions in place of yeast mitochondrial malate dehydrogenase, which catalyzes the oxidation of malate to oxaloacetate in the TCA cycle.

Funder

Japan Society for the Promotion of Science

Research program for the development of intelligent Tokushima artificial exosome (iTEX) from Tokushima University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00168-23

Reference60 articles.

1. WHO. 2022. World malaria report. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2022.

2. Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes

3. Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

4. The multifaceted contributions of mitochondria to cellular metabolism

5. The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Malate dehydrogenase in parasitic protozoans: roles in metabolism and potential therapeutic applications;Essays in Biochemistry;2024-06-28

2. Malate dehydrogenase as a multi-purpose target for drug discovery;Essays in Biochemistry;2024-05-31

3. Insights into the Mechanism of Catalytic Activity of Plasmodium Parasite Malate-Quinone Oxidoreductase;ACS Omega;2024-05-01