Lung Mycobiota α-Diversity Is Linked to Severity in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease-Reference-Cited by-同舟云学术

Lung Mycobiota α-Diversity Is Linked to Severity in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Enaud Raphaël¹²^ORCID,Sioniac Pierre³,Imbert Sebastien¹⁴,Janvier Pierre-Laurent³,Camino Adrian¹,Bui Hoang-Nam³,Pillet Odile³,Orieux Arthur³,Boyer Alexandre¹³,Berger Patrick¹,Gruson Didier¹³,Delhaes Laurence¹⁴,Prevel Renaud¹³^ORCID

Affiliation:

1. Université Bordeaux, Center de Recherche Cardio-Thoracique de Bordeaux, INSERM UMR 1045, Bordeaux, France

2. Centre Hospitalier Universitaire Bordeaux, Le Centre de Ressources et de Compétences de la Mucoviscidose Pédiatrique, CIC 1401, Bordeaux, France

3. Centre Hospitalier Universitaire Bordeaux, Medical Intensive Care Unit, Bordeaux, France

4. Centre Hospitalier Universitaire Bordeaux, Mycology-Parasitology Department, CIC 1401, Bordeaux, France

Abstract

In AECOPD with acidemia, more severe patients— i.e. , nonsurvivors and patients requiring invasive mechanical ventilation—have lower lung mycobiota α-diversity than survivors and patients receiving only noninvasive ventilation, respectively. This study encourages a large multicenter cohort study investigating the role of lung microbiota in severe AECOPD and urges investigation of the role of the fungal kingdom in severe AECOPD.

Funder

Fédération Girondine de Lutte contre les Maladies Respiratoires Chroniques

MD/PhD program CHU Bordeaux

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05062-22

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