Cell Entry of Avian Reovirus Modulated by Cell-Surface Annexin A2 and Adhesion G Protein-Coupled Receptor Latrophilin-2 Triggers Src and p38 MAPK Signaling Enhancing Caveolin-1- and Dynamin 2-Dependent Endocytosis-Reference-Cited by-全球学者库

Cell Entry of Avian Reovirus Modulated by Cell-Surface Annexin A2 and Adhesion G Protein-Coupled Receptor Latrophilin-2 Triggers Src and p38 MAPK Signaling Enhancing Caveolin-1- and Dynamin 2-Dependent Endocytosis

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Huang Wei-Ru¹²,Wu Yi-Ying¹²,Liao Tsai-Ling³⁴⁵,Nielsen Brent L.⁶,Liu Hung-Jen¹²³⁴⁷^ORCID

Affiliation:

1. Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan

2. iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan

3. Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan

4. Ph.D Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan

5. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan

6. Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah, USA

7. Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan

Abstract

By analyzing results from VOPBA and LC-MS/MS, we have determined that cell-surface AnxA2 and ADGRL2 modulate ARV entry. After ARV binding to receptors, Src and p38 MAPK signaling were triggered and, in turn, increased the phosphorylation of caveolin-1 (Tyr14) and upregulated dynamin 2 expression to facilitate caveolin-1–mediated and dynamin 2-dependent endocytosis.

Funder

Ministry of Science and Technology, Taiwan

The ministry of Education in Taiwan

Taichung Veterans General Hospital

National Chung-Hsing University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00009-23

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