Butyrate Protects against Clostridium difficile Infection by Regulating Bile Acid Metabolism-Reference-Cited by-同舟云学术

Butyrate Protects against Clostridium difficile Infection by Regulating Bile Acid Metabolism

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Siqi¹²^ORCID,Xiang Leyang³,li Fang²⁴,Deng Wenlin²,lv Pinjing²,Chen Ye¹⁵^ORCID

Affiliation:

1. Department of Gastroenterology, The First Affiliated of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China

2. Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China

3. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China

4. Department of Gastroenterology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China

5. Department of Gastroenterology, Integrative Clinical Microecology Center, Shenzhen Hospital, Southern Medical University, Shenzhen, China

Abstract

Here, we show that levels of fecal short-chain fatty acids (SCFAs), particularly butyrate, are reduced, and normal colon structure is damaged in patients with CDI compared with those in healthy individuals. Bile acid (BA) metabolic disorder in patients with CDI is characterized by increased primary BA levels and decreased secondary BAs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04479-22

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