Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism-Reference-Cited by-同舟云学术

Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Xia Jiafeng¹²,Lv Longxian¹²^ORCID,Liu Boqiang³,Wang Shuting¹²,Zhang Sitong⁴,Wu Zhengjie¹²,Yang Liya¹²,Bian Xiaoyuan¹²,Wang Qiangqiang¹²,Wang Kaicen¹²^ORCID,Zhuge Aoxiang¹²,Li Shengjie¹²,Yan Ren¹²,Jiang Huiyong¹²,Xu Kaijin¹²,Li Lanjuan¹²

Affiliation:

1. State Key Laboratory for Diagnosis, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China

3. Zhejiang Provincial Key Laboratory of Laparoscopic Technology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

4. Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Abstract

Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, and its hepatoprotective effect was accompanied by activation of the PI3K/Akt pathway and mediated by regulation of the composition and metabolic function of the intestinal microbiota. This finding suggested that the microbial community is a non-negligible impact on drug metabolism and probiotic administration could be a potential therapy for drug-induced liver injury.

Funder

MOST | National Key Research and Development Program of China

NSFC | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01596-21

Reference69 articles.

1. Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions