Erg6 Acts as a Downstream Effector of the Transcription Factor Flo8 To Regulate Biofilm Formation in Candida albicans

Author:

Jin Xueyang1,Luan Xiaoyi1,Xie Fei2,Chang Wenqiang1ORCID,Lou Hongxiang1ORCID

Affiliation:

1. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China

2. Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, Shandong Province, China

Abstract

Biofilm formation by C. albicans hinders its eradication by immune cells and antifungal drugs. Flo8 is an important morphogenetic transcription factor that regulates the biofilm formation and in vivo virulence of C. albicans .

Funder

National Natural Science Foundation of China

Fund for Innovative Team of Shandong University to H.L.

Nature Science Fund for Excellent Young Scholars of Shandong Province of China

Qilu Young Scholars program of Shandong University to W.C.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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