Sub-Inhibitory Concentrations of Oxacillin, but Not Clindamycin, Linezolid, or Tigecycline, Decrease Staphylococcal Phenol-Soluble Modulin Expression in Community-Acquired Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Sub-Inhibitory Concentrations of Oxacillin, but Not Clindamycin, Linezolid, or Tigecycline, Decrease Staphylococcal Phenol-Soluble Modulin Expression in Community-Acquired Methicillin-Resistant Staphylococcus aureus

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hodille Elisabeth¹²^ORCID,Beraud Laetitia¹,Périan Séverine³,Berti Valentine⁴,Bes Michèle¹²⁵,Tristan Anne¹²⁵,Blond Emilie⁶,Lina Gérard¹²⁵^ORCID,Dumitrescu Oana¹²

Affiliation:

1. Department of Bacteriology, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Centre de Biologie Nord, Lyon, France

2. Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Lyon 1, Lyon, France

3. Institut de Génomique Fonctionnelle de Lyon, Lyon, France

4. Assistance Publique des Hôpitaux de Paris, Paris, France

5. National Reference Center for Staphylococci, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Centre de Biologie Nord, Lyon, France

6. Department of Biochemistry and of Molecular Biology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Centre de Biologie Sud, Lyon, France

Abstract

Staphylococcal toxins play an important role in the physiopathology of staphylococcal infections. Subinhibitory concentrations (sub-MIC) of antibiotics modulate in vitro toxins expression in S. aureus : clindamycin (CLI) and linezolid (LIN) display an anti-toxin effect on Panton-Valentine leucocidin and alpha-hemolysin production, while oxacillin (OXA) has an inducing effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00808-21

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