Xpert MTB/RIF Ultra Assay Using Stool: an Effective Solution for Bacilli Identification from Adult Pulmonary Tuberculosis Suspects without Expectorated Sputum-Reference-Cited by-同舟云学术

Xpert MTB/RIF Ultra Assay Using Stool: an Effective Solution for Bacilli Identification from Adult Pulmonary Tuberculosis Suspects without Expectorated Sputum

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yu Xia¹^ORCID,Wang Fen¹,Ren Ruyan¹,Dong Lingling¹,Xue Yi¹,Zhao Liping¹,Jia Junnan¹,Huang Hairong¹^ORCID

Affiliation:

1. National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, Beijing, China

Abstract

This study is aimed at assessing the value of Xpert MTB/RIF Ultra (Xpert-Ultra) in PTB on stool in adult in low HIV settings and Xpert-Ultra assay on stool sample harboring comparable sensitivity with Xpert MTB/RIF on respiratory tract specimens. Although the yield in stool samples by Xpert-Ultra is lower than RTS, it may be useful in detecting disease in presumptive TB patients who cannot expectorate sputum and are not open to BALF collection.

Funder

Natural science fund of China

Beijing Public Health Expert Project

Beijing Hospitals Authority programme

Tongzhou “Yun He” talent project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01265-23

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5. Global Laboratory Initiative. 2014. Laboratory diagnosis of tuberculosis by sputum microscopy – the GLI handbook. https://www.stoptb.org/file/10502/download. Geneva, Switzerland.

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